Ga 68 netspot11/30/2022 ![]() ![]() Monitor Closely (1)lanreotide decreases effects of gallium Ga 68 dotatate by receptor binding competition. Short-acting somatostatin analogs can be used up to 24 hr before imaging with Ga 68 dotatate. Image patients with Ga 68 dotatate PET just prior to dosing with long-acting somatostatin analogs. Somatostatin analogs competitively bind to the same somatostatin receptors as Ga 68 dotatate and may affect imaging. Pasireotide decreases effects of gallium Ga 68 dotatate by receptor binding competition. Octreotide decreases effects of gallium Ga 68 dotatate by receptor binding competition. Patients who take long-acting somatostatin analogues (Sandostatin) should delay this test for 3-4 weeks after their last dose.Lanreotide decreases effects of gallium Ga 68 dotatate by receptor binding competition. Physicians plan to use Netspot PET in order to diagnose neuroendocrine tumors, determine treatment options, plan surgery, and monitor for recurrence. In addition, finding NETs in this manner means the patient would likely be eligible for a new treatment, called Peptide Receptor Radionuclide Therapy (PRRT), that uses hormone-tagged radiation to find and attack the cancer cells. The improved image can help the oncologist choose optimal therapy, such as choosing surgery or systemic therapy. Because PET can be used, the physician gets a very clear, high-resolution image that can identify very small lesions that would otherwise be missed. Completed in a couple hours, this test is much quicker than the onerous three-day octreoscan (which uses a radioactive drug and a gamma camera to measure the radio material over time. ![]() ![]() This imaging approach significantly improves detection of NETs in three important ways: How is it better than current testing methods? Ga-68 dotatate is a radioactive lookalike of the hormone that binds to the somatostatin receptors, highlighting the tumor on PET imaging. While NETs don’t consume glucose like other cancers, their cells do have plenty of receptors for the hormone somatostatin, which regulates the endocrine system. (PET scans normally detect cancer by infusing patients with a glucose preparation and then identifying the body areas where glucose is being consumed or metabolized rapidly.)Ī new agent, gallium-68 dotatate (Netspot ®), recently FDA-approved and available at Roswell Park, can be used as a PET tracer instead of radiolabeled glucose to identify carcinoid tumors even very small lesions significantly better than any currently available imaging. Typical positron emission tomography (PET) scans are not effective in detecting carcinoid tumors, because unlike other cancers, NETs do not consume glucose rapidly. Neuroendocrine Tumor Survivor: Frank's Story ![]()
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